SnapShot: p53 Posttranslational Modifications
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چکیده
منابع مشابه
SnapShot: p53 Posttranslational Modifications
P ho sp ho ry la ti o n N-Terminal: S6, S9, S15, T18, S20 ATM, DNAPK, • CK1 ERKs, ATR, p38 • kinase, mTOR, Chk1/Chk2, JNK, MAPKAP2, Hipk4 Activated by DNA damage, UV light, ionizing radiation, replicative senes• cence, or phosphatidylcholines. N-terminal phosphorylation causes p53 stabilization by inhibiting the p53• MDM2 interaction. Knockin mice carrying separate analogs to human Ser18/ • Ser...
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The latest experimental evidence indicates that acetylation of p53 at K164 (lysine 164) and K120 may induce directly cell apoptosis under severe DNA damage. However, previous cell apoptosis models only studied the effects of active and/or inactive p53, that is, phosphorylation/dephosphorylation of p53. In the present paper, based partly on Geva-Zatorsky et al. (2006) and Batchelor et al. (2008)...
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H2B H3N-PEPAKSA...PKKGSKKAVTKAQKKD...RKRSRKE SYS...YKVLK ...TGISSK...S...SEASRLAHYNKRSTITSRE...VRL ...AKH...GTKAVTKYTSAK-COO10 20 29 30 42 52 64 75 80 90 98 107 114 120 100 Ar Ph Ph Ac Ar Ph OH Ph Ph Ph Ph Me OH Me Ph Ph Ph Me Me Ph Ph Ac Me/Ac/Bu/Cr Hib/Su/Fo Ac Bu Cr Me Ac Bu Cr Hib Me Ac Bu Cr Ac Bu Cr Me/Ac/Bu Cr/Hib/Ub Me Ac Bu Cr Hib Ac Hib Me/Cr/Hib Su/ Ub / Fo Ph Og Me Ac Hib Su Fo Me/A...
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Tissue factor (TF), a membrane protein, is an initiator of blood coagulation in vivo. In this review we discuss how posttranslational modifications affect activity and other properties of TF. Glycosylation of the extracellular domain and the composition of carbohydrates at three glycosylation sites have an influence on TF activity in the extrinsic FXase by increasing the rate of FX proteolysis....
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Taking into account that a large number of nascent gene translation products are subject to limited proteolytic processing, proteolysis is one of the most common PTMs and due to its irreversible nature needs to be very precisely controlled on multiple levels. Since PTMs play a key role in fundamental cellular processes, including the immune response, it is no surprise that these reactions are t...
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ژورنال
عنوان ژورنال: Cell
سال: 2008
ISSN: 0092-8674
DOI: 10.1016/j.cell.2008.05.020